CPD – Podcast FX Medicine: The evolving nature of food allergy management with Emma Sutherland and Dr. Douglas Jones. IgE is an antibody that the body makes that will interact with mast cells and basophils. Mast cells and basophils contain chemicals that ultimately will lead to an allergic reaction. If those chemicals remain inside the cell, nothing happens. However, when those chemicals get released, that’s when they interact and that’s when they cause the symptoms of allergy. The traditional ways to diagnose food allergy are centered on two methods; – Skin prick test – Blood test measuring serum IgE. • Risk factors for food allergy development: • Nutrition of the infant and mother • Early life antibiotic/antacid use • Caesarean birth. • Allergy intervention includes the monitoring of vitamin D levels. • Studies suggest that early life exposure to foods influence immune cells and may protect against food allergy development. • Oral immunotherapy involves introducing a macroscopic amount of food to the allergic patient to retrain the immune system to tolerate the food protein. Overtime this amount is adjusted to increase the threshold of reactivity. • Lifestyle interventions to improve food reactivity and overall gut and immune health: – Exercise – Sleep – Meditation – Relaxation techniques. Dietary and supplemental interventions include: -Pre and probiotics such as lactulose – Omega-3 fatty acids – Vitamin D.